Regulation of plasma free fatty acid turnover-l
نویسنده
چکیده
ARMSTRONG, D. T., R. STEELE, N. ALTSZULER, A. DUNN, J. S. BISHOP, AND R. C. DE BODO. Regulation ofplasmafreefutty acid turnover. Am. J. Physiol. 201 (I> : g-15. 1961 .-Plasma free fatty acid (FFA) turnover rates have been estimated in dogs by a technique involving measurement of FFA specific activities during constant intravenous infusion of trace amounts of Cf4-labeled palmitic acid. In order to determine the relationship between FFA concentration and turnover, variations in plasma FFA levels ranging from 0.081 to 3.3 I pEq/ml were induced by a variety of physiological and pharmacological treatments. Calculated FFA turnover rates ranged from 2.1 to 58.8 pEq/kg/min, with a highly significant linear regression of FFA turnover on FFA level. It is concluded that under a variety of conditions changes in FFA concentration are brought about by changes in FFA production rate and that changes in FFA uptake are simple mass-action effects of changes in FFA concentration. Respiratory C1402 data are presented indicating that about one-fourth of the total expired CO2 is derived from FFA in the postabsorptive state. This accounts for the immediate fate of about onefourth of the total FFA leaving the plasma.
منابع مشابه
Effects of Ramadan fasting on plasma free fatty acids in patients with non-alcoholic fatty liver disease
Introduction: Nonalcoholic fatty liver disease (NAFLD) is a global disease which its prevalence is about 10-35%. Several factors are involved in the pathogenesis of the disease. The present study was conducted to evaluate the effect of fasting during Ramadan on plasma free fatty acids in patients with NAFLD.Methods: This cross-sectional study was performed during the month of Ramadan in June-Ju...
متن کاملThe Effects of Simvastatin on Free Fatty Acids Profile in Fructose-fed Insulin Resistant Rats
Backgrounds: Type 2 diabetes mellitus is the most common metabolic disease and free fatty acids, as signaling molecules, can play a crucial role in the development of it. Different free fatty acids, through various cell membrane receptors, induce different effects on metabolic pathways and thereby affect insulin sensitivity. Simvastatin is a cholesterol decreasing drug prescrib...
متن کاملShort-term effect of nicotinic acid on plasma level and turnover of free fatty acids in sheep and man.
The effects of nicotinic acid on plasma free fatty acid levels and turnover and on plasma glycerol levels were studied in the first few hours after administration to man and the sheep. In both species a fall in all parameters studied was followed by a rise above basal level, interpreted as due to an increase in lipolysis above resting level. The significance of the findings is discussed.
متن کاملCalorigenic Effect of Norepinephrine Correlated with Plasma Free Fatty Acid Turnover and Oxidation.
متن کامل
Plasma free fatty acid transport during prolonged glucose consumption and its relationship to plasma triglyceride fatty acids in man.
Plasma free fatty acid (FFA) transport in human subjects has been studied during the course of prolonged ingestion of different amounts of glucose. Compared with the fasting state, hypocaloric glucose intake resulted in marked suppression of net transport of FFA with no change in (fractional) turnover rate. There was no further suppression of net transport of FFA when the intake was increased t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2004